Matrix therapy has new branch of regenerative medicine and its applications in burned treatment: From fundamental to clinic
D. Barritault, S. Al Harbi, S. Garcia Filipe, V. Plassat and G. Zakine
RGTA®, for Regenerating Agents, form a new class of therapeutics. These molecules are polysaccharides substituted by functionalized groups selected to protect signal proteins called natural growth factors, cytokines, interleukins, chemokines,… against proteolytic degradation These proteins play a key role in cellular communication and are naturally stored in the extracellular matrix via interactions with sulfated polysaccharides such as heparan sulfate.
During tissue damage as burning, enzymes called heparanases degrade heparans sulfates, releasing these cytokines, which are then degraded. RGTA® could protect these cytokines or growth factors. This protection will extend their action and therefore their effectiveness. In the case of burns, this action would result in a modification of the collagen synthesis. This change allows a better repair of the lesion quickly visible on the appearance of tissues. This review presents the first experimental results of the use of RGTA® to treat burns in animal models by showing these actions at the molecular and histological level. Then a case of a human treatment with a medical device CACIPLIQ20® based on RGTA® technology is exposed in the treatment of a burn.