Publications

Abstract: This study aimed to compare incisional wound healing in cats and dogs after the topical application of Manuka honey and a new medical device, Dermapliq. Comparisons were made between each treatment and control, between the two treatments, and between dogs and cats. Twelve cats and twelve dogs were [...]

Gilbert Zakine, MD, PhD; Anne Perruisseau-Carrier, MD, PhD; Corinne Becker, MD; Frédéric Sedel, MD, PhD; Luc Téot, MD; and Denis Barritault, PhD Abstract Background: CACIPLIQ20 (OTR3, Paris, France) is a medical device used for the treatment of chronic skin ulcers. It contains a heparan sulfate mimetic that accelerates tissue [...]

Isabelle Barbosa, Christophe Morin, Stephanie Garcia, Arlette Duchesnay, Mustapha Oudghir, Guido Jenniskens, Hua-Quan Miao, Scott Guimond, Gilles Carpentier, José Cebrian, Jean-Pierre Caruelle, Toin van Kuppevelt, Jeremy Turnbull, Isabelle Martelly, Dulce Papy-Garcia Abstract Crucial events in myogenesis rely on the highly regulated spatiotemporal distribution of cell surface heparan sulfate proteoglycans to [...]

Ahmed M Bata, Katarzyna J Witkowska, Piotr A Wozniak, Klemens Fondi, Gerald Schmidinger, Niklas Pircher, Stephan Szegedi, Valentin Aranha Dos Santos, Anca Pantalon, René M Werkmeister, Gerhard Garhofer, Leopold Schmetterer, Doreen Schmidl Abstract Importance: Corneal abrasions are frequent after standard (epithelium-off [epi-off]) corneal collagen cross-linking (CXL) in patients with progressive [...]

P Desgranges, C Barbaud, J P Caruelle, D Barritault, J Gautron Abstract schemia and denervation of EDL muscle of adult rat induce a large central zone of degeneration surrounded by a thin zone of peripheral surviving muscle fibers. Muscle regeneration is a complex phenomenon in which many agents interact, such [...]

Q Escartin, C Lallam-Laroye, B Baroukh, F O Morvan, J P Caruelle, G Godeau, D Barritault, J L Saffar Abstract Periodontitis are diseases of the supportive tissues of the teeth provoked by bacteria and characterized by gingival inflammation and bone destruction. We have developed a new strategy to repair tissues [...]

Yacine Khelif, Jérôme Toutain, Marie-Sophie Quittet, Sandrine Chantepie, Xavier Laffray , Samuel Valable, Didier Divoux , Fernando Sineriz, Emanuelle Pascolo-Rebouillat, Dulce Papy-Garcia, Denis Barritault, Omar Touzani, Myriam Bernaudin Abstract Alteration of the extracellular matrix (ECM) is one of the major events in the pathogenesis of brain lesions following ischemic stroke. [...]

P Mestries, C Alexakis, D Papy-Garcia, A Duchesnay, D Barritault, J P Caruelle, P Kern Abstract Regenerating agents (RGTA) are defined as heparan sulfate mimics, which in vivo stimulate tissue repair. RGTA are obtained by controlled grafting of carboxymethyl and sulfate groups on dextran polymers. RGTA are selected in vitro, [...]

Miao Tong, Bastiaan Tuk, Peng Shang, Ineke M Hekking, Esther M G Fijneman, Marnix Guijt, Steven E R Hovius, Johan W van Neck Abstract Wound healing in diabetes is frequently impaired, and its treatment remains a challenge. We tested a therapeutic strategy of potentiating intrinsic tissue regeneration by restoring the [...]