The RGTA® technology promotes tissue healing
and regeneration by Matrix Therapy

Technology
Technology

RGTA® Technology and Mechanism of Action

RGTA®
Technology
and Mechanism of Action

RGTA® technology is based upon the central role of the extracellular matrix (ECM) in cellular turnover or the replacement of a dying cell by another identical cell within a tissue or organ. This continuous renewal process or homeostasis is regulated by specific signals (or communication peptides such as growth factors) in the extracellular space surrounding cells. These signals are stored, protected, and positioned on a family of large polysaccharides called heparan sulfates (HS), that act as an element of the scaffolding inside the extracellular matrix by bridging matrix proteins (such as collagen, elastine , etc…) through dedicated protein binding sites.

Following an injury, and as part of the natural tissue healing process, immune and inflammatory circulatory cells aggregate at the site of the lesion and actively participate in the degradation process that precedes tissue repair through the release of enzymes which destroy the ECM components including heparan sulfate, leaving the communication peptides unprotected and able to be degraded.

Tissue lesions initiate the degradation of the extracellular environment

Tissue lesions initiate the degradation of the extracellular environment

Tissue lesions initiate the degradation of the extracellular environment

The “emergency” signals to repair the injury, controlled by the inflammatory and immune cells, are not tissue specific and the repair process is more focused on bridging wound openings rather than preserving tissue homeostasis. This “emergency” repair often leaves marks, scars or fibrosis, all leading to a loss of tissue quality and functionality.

Alternatively, this “emergency” repair may be only partially effective, leading to a chronic wound, blocked in a persistent inflammatory cycle that can go on for years before healing, often with fibrotic or scared tissue.

Dysfunctional tissue repair leads to fibrosis or a chronic wound

Dysfunctional tissue repair leads to fibrosis or a chronic wound

Dysfunctional tissue repair leads to fibrosis or a chronic wound

RGTA® molecules, specifically designed to be more resistant to enzymatic degradation, provide a temporary substitute for the degraded Heparan Sulfates (HS}, while maintaining their natural ability to bind and protect communication peptides. RGTA® molecules also help to reconstruct the spatial organization of the extracellular matrix (ECM), as they can attach to other ECM components such as collagen and hyaluronic acid to act as a scaffold allowing it to properly reorganize.

RGTA® helps restore the extracellular matrix for effective tissue regeneration

RGTA® helps restore the extracellular matrix for effective tissue regeneration

RGTA® helps restore the extracellular matrix for effective tissue regeneration

In short, RGTA® molecules interact with ECM components to protect tissue specific endogenous communication peptides and scaffold proteins by blocking access of degrading enzymes. As the tissue regeneration process resumes, natural HS that are continuously produced by neighboring cells will progressively recover their role in the healing tissue, until complete healing is achieved.

When applied onto a wound, RGTA® molecules allow the natural regeneration process to resume, restoring the initial tissue homeostasis.

Extracellular Matrix Degradation

A body lesion will degrade the cells and the environment around them (extracellular matrix)

Tissue Repair without RGTA®

Important lesions are followed by incomplete tissue regeneration leading to loss of quality (scar, fibrosis)

Tissue Regeneration with RGTA®

RGTA® molecules protect the natural extracellular matrix environment and promote full tissue regeneration

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