CACIPLIQ20® – Foot Ulcer
Efficacy of a New Heparan Sulfate Mimetic Dressing in the Healing of Foot and Lower
Extremity Ulcerations in Type 2 Diabetes: A Case Series
Nikolaos Papanas, Costas Demetzos, Natassa Pippa, Efstratios Maltezos and Nicholas Tentolouris
A novel heparan sulfate glycosaminoglycan mimetic product for local application to promote wound healing (CACIPLIQ20) has recently become available.
It is a biophysical therapeutic product comprising a polysaccharide as an innovative biomaterial to accomplish mechanical tissue engineering and skin regeneration in the site of ulceration.
We present a series of 12 patients with type 2 diabetes (4 men and 8 women; age 53-87 years; diabetes duration 8-25 years) having chronic resistance to therapy for foot and lower extremity ulcerations.
CACIPLIQ20 was locally applied twice per week after careful debridement. Complete ulcer healing was accomplished in all patients after a mean treatment duration of 4.92 months (range = 2-12 months). The product was very well tolerated.
In conclusion, these results, although preliminary, are encouraging and suggest adequate efficacy and safety of the new product in difficult-to-heal foot and lower extremity ulcerations in type 2 diabetes.