Pipeline map including
next generation Matrix Therapies with RGTA®
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Clinical Pipeline

Clinical Pipeline

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OTR3 focuses on high potential programs
including award winning key projects.

Preclinical Pipeline

Preclinical Pipeline

OTR3 focuses on key development projects with high potential, with the aim of exploiting the versatility of the RGTA® technology to provide to patients new healthcare products that really matter.

The following development programs, relying on the regenerating potential of RGTA® molecules,  are just only a fraction of the technology’s potential, and are to date the closer to market.

The excellence and potential of OTR3’s Pipeline has been confirmed by awards and grants (H2020 SME Instrument, Medicen Label, ANR grant, INCA)

Neurology

Stroke Management

Funding

Stroke management through RGTA®: SMR

H2020 811729

 


Acute ischemic stroke

Funding

La thérapie matricielle pour l’ischémie cérébrale : une nouvelle opportunité pour protéger le tissu cérébral en souffrance et pour promouvoir sa régénération ?

ANR-15-CE18-0029 MAESTRO: https://anr.fr/Projet-ANR-15-CE18-0029


Acute ischemic stroke

Funding

A matrix therapy to optimize MSC-derived extracellular vesicles for brain protection and repair after ischemia

ANR-21-CE18-0029: https://anr.fr/Projet-ANR-21-CE18-0029

Publications 

A heparan sulfate-based matrix therapy reduces brain damage and enhances functional recovery following stroke. 2018. 


Brain protection after radiotherapy

Funding

Matrix Therapy against Radiotherapy-Induced Brain damage and Cognitive deficits (Brain-MATRiX)

INCa-Brain-Matrix: 2021-068 https://www.e-cancer.fr/Institut-national-du-cancer/Appels-a-projets/Appels-a-projets-resultats/PLBIO2021


Alzheimer’s disease and tauopathies

Publications

Protective Effects of a synthetic glycosaminoglycan mimetic (OTR4132) in a rat immunotoxic lesion model of septohippocampal cholinergic degeneration. 2022

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds. 2013

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Pipeline
Pipeline

Organes Tissus Regeneration Reparation Remplacement

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75001 Paris, France

© 2022 – OTR3 – All rights reserved