Développements clés
OTR3 se focalise sur des développements clés, aussi bien au stade clinique que préclinique, répondant à notre mission et explorant les indications les plus prometteuses de la technologie des RGTA®.
Le potentiel des études OTR3 a été confirmé par de nombreuses récompenses et subventions (H2020 SME Instrument, Medicen Label, ANR, INCA).
Études cliniques
Études précliniques
Stroke Management
Funding
Stroke management through RGTA®: SMR
H2020 811729
Acute ischemic stroke
Funding
La thérapie matricielle pour l’ischémie cérébrale : une nouvelle opportunité pour protéger le tissu cérébral en souffrance et pour promouvoir sa régénération ?
ANR-15-CE18-0029 MAESTRO: https://anr.fr/Projet-ANR-15-CE18-0029
Acute ischemic stroke
Funding
A matrix therapy to optimize MSC-derived extracellular vesicles for brain protection and repair after ischemia
ANR-21-CE18-0029: https://anr.fr/Projet-ANR-21-CE18-0029
Publications
A heparan sulfate-based matrix therapy reduces brain damage and enhances functional recovery following stroke. 2018.
Brain protection after radiotherapy
Funding
Matrix Therapy against Radiotherapy-Induced Brain damage and Cognitive deficits (Brain-MATRiX)
INCa-Brain-Matrix: 2021-068 https://www.e-cancer.fr/Institut-national-du-cancer/Appels-a-projets/Appels-a-projets-resultats/PLBIO2021
Alzheimer’s disease and tauopathies
Publications
Protective Effects of a synthetic glycosaminoglycan mimetic (OTR4132) in a rat immunotoxic lesion model of septohippocampal cholinergic degeneration. 2022
Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds. 2013
Acute lung diseases
Funding
Heparan Sulfate Mimetics as a New Therapy for Acute Pulmonary Lesions
ANR-22-CE18-0013 / https://anr.fr/Projet-ANR-22-CE18-0013
Publications
Heparan Sulfate Mimetics as a New Therapy for Acute Pulmonary Lesions.
Radiotherapy treatment
Funding
Synthèse sonoélectrochimique de nanoparticules de phosphate de calcium pour hydrogels injectables
ANR-18-CE18-0014: https://anr.fr/Projet-ANR-18-CE18-0014
Publications
Heparan-mimetics: Potential agents of tissue regeneration for bone and periodontal therapies. 2021
Periodontal reconstruction by heparan sulfate mimetic-based matrix therapy in Porphyromonas gingivalis-infected mice. 2018
Glycosaminoglycan mimetic associated to human mesenchymal stem cell-based scaffolds inhibit ectopic bone formation, but induce angiogenesis in vivo. 2013
Kinetic study of early regenerative effects of RGTA11, a heparan sulfate mimetic, in rat craniotomy defects.
Type-2 Diabetes
Funding
Développement de molécules libératrices de monoxyde de carbone conjuguées à des polysaccarides pour cibler le tissu adipeux dans l’obésité.
ANR-19-CE18-0032: https://anr.fr/Projet-ANR-19-CE18-0032
Publications
DEVELOPMENT OF CARBON MONOXIDE-RELEASING MOLECULES CONJUGATED TO POLYSACCHARIDE CARRIERS TARGETING ADIPOSE TISSUE FOR THE TREATMENT OF OBESITY
Skin lesions
Funding
Skin tissue engineering and regenerative medicine: from skin repair to regeneration
H2020-MSCA-ITN-2020-SkinTerm-955722
Publications
Skin Tissue Engineering and Regenerative Medicine: From skin repair to regeneration
Periodontitis
Publications
A new approach to treat tissue destruction in periodontitis with chemically modified dextran polymers. 2003
Periodontitis destructions are restored by synthetic glycosaminoglycan mimetic. 2006
ReGeneraTing agents matrix therapy regenerates a functional root attachment in hamsters with periodontitis. 2011
Periodontal reconstruction by heparan sulfate mimetic-based matrix therapy in Porphyromonas gingivalis-infected mice. 2018
Heparan-mimetics: Potential agents of tissue regeneration for bone and periodontal therapies. 2021
Cornea lesions
Available soon…
