Key developments

OTR3 focuses on key advances, both clinical and preclinical, fulfilling our mission to explore the most promising indications of RGTA® technology.

The potential benefit of these OTR3 studies has been confirmed by numerous awards and grants (H2020 SME Instrument, Medicen Label, ANR, INCA).

Preclinical studies

Etudes cliniques autour des RGTA

Preclinical studies

Stroke Management

Funding
Stroke management through RGTA®: SMR
H2020 811729

Acute ischemic stroke

Funding
La thérapie matricielle pour l’ischémie cérébrale : une nouvelle opportunité pour protéger le tissu cérébral en souffrance et pour promouvoir sa régénération ?
ANR-15-CE18-0029 MAESTRO: https://anr.fr/Projet-ANR-15-CE18-0029

Acute ischemic stroke

Funding
A matrix therapy to optimize MSC-derived extracellular vesicles for brain protection and repair after ischemia
ANR-21-CE18-0029: https://anr.fr/Projet-ANR-21-CE18-0029

Publications
A heparan sulfate-based matrix therapy reduces brain damage and enhances functional recovery following stroke. 2018.

Brain protection after radiotherapy

Funding
Matrix Therapy against Radiotherapy-Induced Brain damage and Cognitive deficits (Brain-MATRiX)
INCa-Brain-Matrix: 2021-068 https://www.e-cancer.fr/Institut-national-du-cancer/Appels-a-projets/Appels-a-projets-resultats/PLBIO2021

Alzheimer’s disease and tauopathies

Publications
Protective Effects of a synthetic glycosaminoglycan mimetic (OTR4132) in a rat immunotoxic lesion model of septohippocampal cholinergic degeneration. 2022
Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds. 2013

Acute lung diseases

Funding
Heparan Sulfate Mimetics as a New Therapy for Acute Pulmonary Lesions
ANR-22-CE18-0013 / https://anr.fr/Projet-ANR-22-CE18-0013

Publications
Heparan Sulfate Mimetics as a New Therapy for Acute Pulmonary Lesions.

Radiotherapy treatment

Funding
Synthèse sonoélectrochimique de nanoparticules de phosphate de calcium pour hydrogels injectables
ANR-18-CE18-0014: https://anr.fr/Projet-ANR-18-CE18-0014

Publications

Heparan-mimetics: Potential agents of tissue regeneration for bone and periodontal therapies. 2021
Periodontal reconstruction by heparan sulfate mimetic-based matrix therapy in Porphyromonas gingivalis-infected mice. 2018
Glycosaminoglycan mimetic associated to human mesenchymal stem cell-based scaffolds inhibit ectopic bone formation, but induce angiogenesis in vivo. 2013
Kinetic study of early regenerative effects of RGTA11, a heparan sulfate mimetic, in rat craniotomy defects.

Type-2 Diabetes

Funding
Développement de molécules libératrices de monoxyde de carbone conjuguées à des polysaccarides pour cibler le tissu adipeux dans l’obésité.
ANR-19-CE18-0032: https://anr.fr/Projet-ANR-19-CE18-0032

Publications
DEVELOPMENT OF CARBON MONOXIDE-RELEASING MOLECULES CONJUGATED TO POLYSACCHARIDE CARRIERS TARGETING ADIPOSE TISSUE FOR THE TREATMENT OF OBESITY

Skin lesions

Funding
Skin tissue engineering and regenerative medicine: from skin repair to regeneration
H2020-MSCA-ITN-2020-SkinTerm-955722

Publications
Skin Tissue Engineering and Regenerative Medicine: From skin repair to regeneration

Periodontitis

Publications
A new approach to treat tissue destruction in periodontitis with chemically modified dextran polymers. 2003
Periodontitis destructions are restored by synthetic glycosaminoglycan mimetic. 2006
ReGeneraTing agents matrix therapy regenerates a functional root attachment in hamsters with periodontitis. 2011
Periodontal reconstruction by heparan sulfate mimetic-based matrix therapy in Porphyromonas gingivalis-infected mice. 2018
Heparan-mimetics: Potential agents of tissue regeneration for bone and periodontal therapies. 2021

Cornea lesions

Available soon…

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