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Lungs/Poumons

  • November 2024 – Successful Development of Human Precision-Cut Lung Slice (hPCLS) Model for Studying Lung Disease

    Lungs/Poumons | Media Publications

    Laurie Perdigon (1) , Manon Barthe (1) , Hanan Osman-Ponchet (1) , Agnes Choppin (2) , Franck Chiappini (2) Human precision-cut lung slices (hPCLS) are a promising ex vivo model for respiratory research. These thin, precisely-cut tissues, obtained from fresh lungs using a vibrating microtome, retain the native 3D architecture [...]

  • November 2024 – Screening Anti-Fibrotic Drugs Using Primary Human Pulmonary Fibroblasts: A Cell Migration and Gene Expression Assay

    Lungs/Poumons | Media Publications

    Manon Barthe (1) , Laurie Perdigon (1) , Hanan Osman-Ponchet (1) , Agnès Choppin (2) , Franck Chiapini (2) Pulmonary fibrosis is a progressive, restrictive lung disease characterized by scarring and stiffening of lung tissue, ultimately leading to respiratory failure. This condition is driven by the excessive proliferation and migration [...]

  • November 2024 – SUCCESSFUL GENERATION OF THREE-DIMENSIONAL HUMAN PRECISION-CUT LUNG SLICES FOR PULMONARY FIBROSIS MODELING

    Lungs/Poumons | Media Publications

    Laurie Perdigon (1) , Manon Barthe (1) , Jean-Paul Thénot (1) , Franck Chiappini (2) , Agnes Choppin (2) , Hanan Osman-Ponchet (1) Occurrence of diffuse alveolar damage is a real storm in the course of pulmonary diseases leading to an acute and/or chronic inflammatory processes with poorly understood etiologies [...]

  • November 2024 – Advances in In Vitro Modeling of Pulmonary Fibrosis: Focus on Precision-Cut Lung Slices (PCLS) Model

    Latest Publications | Lungs/Poumons | Media Publications | On-going research

    Hanan Osman-Ponchet (1) , Laurie Perdigon (1) , Manon Barthe (1) , Ines Metatla (2) , Kevin Rogers (2) , Ida Chiara Guerrera (2) , Franck Chiappini (3) , Agnes Choppin (3) Pulmonary fibrosis is a progressive lung disease characterized by scarring and stiffening of lung tissue, ultimately leading to [...]

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