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Overview of 10 years of practice with CACIPLIQ20® matrix therapy as a healing agent for hard to heal wounds: Efficacy, cost-effectiveness and future perspectives Background: Chronic, non-healing wounds remain a major challenge for health care practitioners and for society in general, both in terms of the enormous economic burden [...]
18 March 2025
Merel Gansevoort 1 , SabineWentholt 1, Gaia Li Vecchi 1, Marjolein de Vries 1, Elly M. M. Versteeg 1, Bouke K. H. L. Boekema 2,3 , Agnes Choppin 4, Denis Barritault 4, Franck Chiappini 4 , Toin H. van Kuppevelt 1 and Willeke F. Daamen 1,* Fibrosis after full-thickness wound [...]
11 February 2025
Q Escartin, C Lallam-Laroye, B Baroukh, F O Morvan, J P Caruelle, G Godeau, D Barritault, J L Saffar Abstract Periodontitis are diseases of the supportive tissues of the teeth provoked by bacteria and characterized by gingival inflammation and bone destruction. We have developed a new strategy to repair tissues [...]
31 May 2022
Yacine Khelif, Jérôme Toutain, Marie-Sophie Quittet, Sandrine Chantepie, Xavier Laffray , Samuel Valable, Didier Divoux , Fernando Sineriz, Emanuelle Pascolo-Rebouillat, Dulce Papy-Garcia, Denis Barritault, Omar Touzani, Myriam Bernaudin Abstract Alteration of the extracellular matrix (ECM) is one of the major events in the pathogenesis of brain lesions following ischemic stroke. [...]
31 May 2022
P Mestries, C Alexakis, D Papy-Garcia, A Duchesnay, D Barritault, J P Caruelle, P Kern Abstract Regenerating agents (RGTA) are defined as heparan sulfate mimics, which in vivo stimulate tissue repair. RGTA are obtained by controlled grafting of carboxymethyl and sulfate groups on dextran polymers. RGTA are selected in vitro, [...]
27 May 2022
Miao Tong, Bastiaan Tuk, Peng Shang, Ineke M Hekking, Esther M G Fijneman, Marnix Guijt, Steven E R Hovius, Johan W van Neck Abstract Wound healing in diabetes is frequently impaired, and its treatment remains a challenge. We tested a therapeutic strategy of potentiating intrinsic tissue regeneration by restoring the [...]
27 May 2022
Denis Barritault, Marie Gilbert-Sirieix, Kim Lee Rice, Fernando Siñeriz, Dulce Papy-Garcia, Christophe Baudouin, Pascal Desgranges, Gilbert Zakine, Jean-Louis Saffar, Johan van Neck Abstract The importance of extracellular matrix (ECM) integrity in maintaining normal tissue function is highlighted by numerous pathologies and situations of acute and chronic injury associated with dysregulation [...]
27 May 2022
Clerapliq -RGTA® or ReGeneraTing Agents mimic heparan sulfate in regenerative medicine: from concept to curing patients Denis Barritault & Marie Gilbert-Sirieix & Kim Lee Rice & Fernando Siñeriz & Dulce Papy-Garcia & Christophe Baudouin & Pascal Desgranges & Gilbert Zakine & Jean-Louis Saffar8 & Johan van Neck Abstract The [...]
12 May 2022
