The RGTA® technology promotes tissue healing
and regeneration by Matrix Therapy
The tissues of the human body possess the natural ability to repair themselves in several ways. In some tissues such as skin, liver or bone, cells that die are replaced by new identical cells. In other tissues where cells have lost the ability to multiply, such as the nervous system, surviving cells have the ability to change their connections and take the place of failing cells. This ability of tissues to regenerate or repair itself is controlled in part by signals, or communication peptides, stored outside cells in what is called the extracellular matrix.
However, the self-repair capacities of tissues are exceeded when many cells die at the same time. In this case, the damaged tissue is repaired urgently, which leaves traces such as scars or fibrosis. The incomplete nature of the repair is partly linked to the destruction of the extracellular matrix, which indirectly leads to a loss of communication peptides and therefore of the information necessary for proper tissue repair.
RGTA® Technology and Mechanism of Action
Regenerating Agents (RGTA®) technology is based on the central role of the extracellular matrix (ECM) in the repair (or regeneration) of tissues and organs.
This regeneration process is regulated by specific signals, the communication peptides, present in the ECM where they are stored, protected and positioned within a family of polysaccharides called heparan sulphates (HS), which form a scaffold with the matrix proteins (like collagen).
During tissue damage, enzymes are released which destroy the components of the ECM including heparan sulphates which leads to an accelerated degradation of the communication peptides.
RGTAs are complex sugars that mimic natural heparan sulfates while being resistant to degradation enzymes.
The main action of RGTA® is to replace degraded heparan sulfates and consequently restore the scaffolding of the extracellular matrix through direct physical interactions with proteins (collagens and glycoproteins). As a consequence of the restoration of the scaffold, the communication peptides are protected leading to better tissue regeneration: